Libraries frequently encounter contaminated materials—from mold and fluids to bed bugs and other pests—that can pose risks to staff, patrons, and collections. This session equips library staff with the knowledge and tools to safely identify, isolate, and manage contaminated or infested materials while minimizing disruption to services. Participants will learn best practices for containment, cleaning, and communication, using real-world examples from Enoch Pratt Free Library and State Library Resource Center. Attendees will leave prepared to adapt or strengthen their own library’s policies and maintain a safer environment for all.